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Exosomes: What are they? How do they work? And are they safe?

Exosomes are the messengers cells use to talk to each other. Paired with microneedling, they deliver regenerative signals exactly where the skin is repairing.

Medically reviewed by Dr Rakib Uddin AHPRA MED0001936872 3 min read

Editorial macro of the surface of a cheek in hard raking light

The short answer

Exosomes are the messengers cells use to talk to each other. Paired with microneedling, they deliver regenerative signals exactly where the skin is repairing.

Reads with Microneedling

Microneedling with exosomes being applied to the skin at Aesthetic Doctors Australia in Melbourne

Microneedling and exosomes treatment, Melbourne

Exosomes are tiny vesicles that cells release to carry signals to other cells. In aesthetic skin treatments they are used topically, most often straight after microneedling, so that those signals reach the skin while it is repairing. The exosomes used at Aesthetic Doctors Australia are plant derived and contain no human cells or human DNA.

They are also one of the most talked-about innovations in regenerative medicine right now, so you have probably seen them cropping up in skincare, injectable treatments and post-procedure recovery protocols. Below is what exosomes actually are, how they are used with microneedling, and what can and cannot be said about their safety.

What exactly are exosomes?

Exosomes are microscopic extracellular vesicles, think of them as tiny parcels of communication, that are naturally released by nearly every cell in the body. They carry powerful signals, including proteins and lipids from one cell to another. This is how cells communicate, repair, and regenerate.

In aesthetics, we use exosomes derived from plants, applied to the surface of the skin rather than injected, to support skin healing, collagen production and cellular renewal. They are used alongside a treatment rather than on their own, and the pairing we use most is microneedling.

Why microneedling and exosomes work so well together?

Microneedling creates thousands of controlled micro-injuries in the skin, which kickstarts the body's natural repair process and opens up channels for deeper product absorption. When we apply exosomes during and immediately after microneedling, those powerful regenerative molecules are delivered right into the skin, where they can get to work more effectively.

The aim is to support the skin's own repair in the days after the session, so that recovery is calmer and the result of the microneedling is better than it would be alone. What any individual notices varies, and exosomes are an adjunct to the microneedling rather than a treatment that works by itself. If you are weighing exosomes against the other regenerative option we offer, the comparison of exosomes and polynucleotides sets out which concern each one suits.

Are exosomes safe to use with microneedling?

What matters is the source and the quality of the product, and how it is used. The formulations we use are plant based and free from DNA, cells and biologically active human material. They are purified and stabilised for consistency, and they are made for topical application in aesthetic treatments rather than for injection. Whether they are appropriate for you, and whether microneedling itself is, is decided at assessment: skin that is actively inflamed or infected, some medical histories and some medications all change the answer. Every treatment carries some risk, and the risks of the microneedling and of any product used with it are explained to you before you consent.

So, should you try exosome therapy?

Exosomes are incredibly promising. They're part of a wider shift in aesthetics towards regenerative treatments that focus on improving skin function, not just appearance. But like any treatment, they're not a silver bullet. The results can be subtle, and they work best as part of a comprehensive plan, paired with the right skincare, in-clinic treatments, and a lifestyle that supports healthy skin from within.

If you're curious about exosomes and whether they're a good fit for your skin concerns or treatment goals, I'd be happy to explore this with you. As with all treatments, it starts with a conversation, and a plan tailored just for you. When you are ready, you can book a consultation at Aesthetic Doctors Australia, or read what the microneedling treatment itself involves.

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1167 Burke Road, Kew VIC 3101

Important treatment information

All information on this page is general in nature and is not a substitute for a medical consultation. Any before-and-after images shown are for illustrative purposes only and do not guarantee individual outcomes. Treatments performed by Dr Rakib Uddin (AHPRA MED0001936872) vary based on each patient's unique anatomy, medical history and needs. All cosmetic injectable treatments carry risks; a consultation is required prior to any treatment to assess suitability, discuss risks and alternatives, and establish realistic expectations.

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